30) Prenatal and early postnatal supplementation with long-chain polyunsaturated fatty acids: neurodevelopmental considerations

Hadders-Algra M Am J Clin Nutr. 2011 Dec; 94(6 Suppl):1874S-1879S.

Neonatal concentrations of DHA and arachidonic acid are associated with improved outcomes in early infancy, and concentrations of DHA are associated with favorable Neurodevelopmental outcome beyond early infancy the highest concentrations of DHA and AA are found in the basal ganglia, hippocampus, thalamus, cerebellum, and precentral, postcentral, prefrontal, and occipital cortices—a finding that suggests that LC-PUFA intake particular affect the circuitries involved in sensorimotor integration, attention-executive function, and memory.

DHA accretion in the central nervous system depends on the dietary provision of DHA, ie, on the duration and concentration of DHA supplementation.
DHA Varied between 200 and 2200mg/d, age at evaluation from a few days to 7 y, and functional domain from visual acuity, motor control, and cognitive function to behavioral adaptation.

Prenatal and neonatal DHA and AA concentrations are related to
Neurodevelopmental outcome in early infancy, but only prenatal and neonatal DHA is associated with outcomes beyond early infancy.