12) N-Docosahexaenoyl ethanolamine promotes development of Hippocampal neurons

Kim et al. Biochem J. 2011 April 15; 435(2): 327–336

“Docosahexaenoic acid (DHA) promotes neurite development, synaptogenesis and expression of synapsins and glutamate receptors, which in turn leads to improved synaptic transmission”

“Docosahexaenoic acid (DHA) metabolism to DEA is a key mechanism leading to enhanced synaptic function through promoted hippocampal neurodevelopment”

“The metabolism of DHA to DEA is a novel and significant mechanism for hippocampal neuronal development and function. DEA produced from DHA promotes neurite development, synaptogenesis and expression of synapsins and glutamate receptors, which in turn leads to improved synaptic transmission”.

“Since DEA is derived from DHA, compromised DEA-dependent hippocampal development may be an underlying mechanism for the learning disability and memory deficit associated with neural DHA depletion due to dietary deficiencies of n−3 fatty acids”.